2. Signaling Pathways
  3. Stem Cell/Wnt
  4. BMI1
  5. BMI1 Inhibitor

BMI1 Inhibitor

BMI1 Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-15888
    PTC-209
    		Inhibitor 99.85%
    PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment.
  • HY-112041
    Unesbulin
    		Inhibitor 99.45%
    Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity.
  • HY-103696
    PTC-028
    		Inhibitor ≥98.0%
    PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. PTC-028 selectively inhibits cancer cells whereas normal cells remain unaffected. PTC-028 downregulates BMI-1, inducing caspase-mediated apoptosis.
  • HY-15888A
    PTC-209 hydrobromide
    		Inhibitor 99.44%
    PTC-209 hydrobromide is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 hydrobromide irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 hydrobromide shows potent anti-myeloma activity and impairs the tumor microenvironment.
  • HY-143658
    SH498
    		Inhibitor
    SH498, a novel Bmi-1-mediated antitumor agent, shows potent antiproliferative activity.
  • HY-143655
    QW24
    		Inhibitor
    QW24 exerts potent anti-tumor activity by down-regulating BMI-1 and is used as an effective therapeutic agent for clinical colorectal cancer research.
  • HY-N0992
    1,6,7-Trihydroxyxanthone
    		Inhibitor
    1,6,7-Trihydroxyxanthone is a potent anticancer agent. 1,6,7-Trihydroxyxanthone inhibits cell proliferation and induces cell Apoptosis. 1,6,7-Trihydroxyxanthone decreases Bmi-1 expressio and increases the protein levels expression of P14, P16.