2. Signaling Pathways
  3. Immunology/Inflammation
  4. Cyclic GMP-AMP Synthase
  5. Cyclic GMP-AMP Synthase Activator

Cyclic GMP-AMP Synthase Activator

Cyclic GMP-AMP Synthase Activators (2):

Cat. No. Product Name Effect Purity
  • HY-159925
    QKY-613
    		Activator
    QKY-613 is a prodrug that enhances immune surveillance by targeting nucleic acid modification pathways. QKY-613 promotes the selective incorporation of 6mdA (N6-methyldeoxyadenosine) into viral DNA, enhancing the phase separation potential of DNA, thereby increasing the activation of cGAS and strengthening host immune surveillance. In virus-infected mouse models, QKY-613 significantly reduced mortality in aged mice. QKY-613 holds promise for research on nucleic acid modification-based immune surveillance mechanisms.
  • HY-138646
    Poly(deoxyadenylic-thymidylic) acid sodium
    		Activator
    Polydeoxyadenylic-thymidylic acid (Poly(dA:dT)) sodium is a synthetic DNA polymer. Poly(dA:dT) sodium can be used to determine the activity of bound and free ribonucleic acid polymerase. Poly(dA:dT) sodium is recognized by multiple PRRs (cytosolic DNA sensors (CDS), including cGAS, AIM2, DAI, DDX41, IFI16, and LRRFIP1), and triggers the production of type I interferons. Poly(dA:dT) sodium can be used for the research of cancer and virus infection.