2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Factor VIIa

Factor VIIa

Factor VIIa

Factor VIIa is the active form of factor VII and plays an important role in the process of blood coagulation. Factor VIIa can combine with tissue factor to form a complex, activating factor IX and factor X, thereby promoting blood coagulation. In addition, when there is vascular injury, factor VIIa can quickly initiate the blood coagulation process, forming a fibrin clot at the site of injury to achieve physiological hemostasis. Factor VIIa is closely related to diseases. Its deficiency can lead to excessive bleeding, and an excessively high level of it can increase the risk of thrombotic diseases. Factor VIIa, due to its well-known ability to promote coagulation, is also used as a hemostatic agent in the treatment of several hyper bleeding disorders like hemophilia, thrombocytopenia etc[1][2].

Factor VIIa Related Products (5):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16382
    PCI-27483
    		Inhibitor 98.72%
    PCI-27483 is a FVIIa/tissue factor inhibitor, with antitumour effects.
    PCI-27483
  • HY-114511
    BMS-593214
    		99.90%
    BMS-593214 is an active site-directed factor (F) VIIa inhibitor. BMS-593214 shows antithrombotic and antihaemostatic properties. BMS-593214 is a direct competitive inhibitor of human FVIIa and a non-competitive inhibitor of Viia-activated substrate FX. BMS-593214 prevents electroinduced carotid artery thrombosis (AT) and wire induced vena cava thrombosis (VT).
    BMS-593214
  • HY-153480A
    ARC19499 sodium
    		Inhibitor
    ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.
    ARC19499 sodium
  • HY-P3235
    E-76
    E-76 is a peptide with anticoagulant activity. E-76 inhibits blood coagulation by specifically binding to exogenous coagulation factor VIIa (FVIIa). E-76 can be used to study blood coagulation-related diseases.
    E-76
  • HY-E70393
    Human Factor VIIa
    Human Factor VIIa is a vitamin K-dependent serine protease that is involved in the blood coagulation process. Human Factor VIIa activates Factor X, which causes the conversion of prothrombin to thrombin and the conversion of fibrinogen to fibrin, leading to the formation of blood clots. Human Factor VIIa exhibits the potential to ameliorate Hemophilia.
    Human Factor VIIa