2. Signaling Pathways
  3. Epigenetics
  4. METTL3
  5. METTL3 Degrader

METTL3 Degrader

METTL3 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-162930
    PROTAC METTL3 degrader 1
    		Degrader
    PROTAC METTL3 degrader 1 (Compound KH12) is a VHL-based PROTAC METTL3 degrader (DC50: 220 nM in MOLM-13 cells). PROTAC METTL3 degrader 1 inhibits METTL3/14 complex with an IC50 value of 341 nM. PROTAC METTL3 degrader 1 has anti-proliferative activities against AML cells. Black: Linker (HY-ER002); Red: METTL3 ligand (HY-115717); Blue: VHL ligand (HY-120217).