2. Signaling Pathways
  3. Immunology/Inflammation
  4. MHC

MHC

Major Histocompatibility Complex; MHC

MHC is a group of genes encoding proteins which are transferred to the cell surfaces to present the intracellular or extracellular, self or non-self antigens to the cells of the immune system, thereby helping T cells in differentiating self from non-self proteins, and initiating adaptive immune responses. MHC can be divided into 3 subtypes, MHC I, MHC II and MHC III, in which MHC I presents endogenous antigens (such as antigens produced by virus-infected cells or tumor cells) to activate cytotoxic T cells (CD8+ T cells); MHC II presents exogenous antigens (such as bacteria or parasites) to activate helper T cells (CD4+ T cells); MHC III does not directly participate in antigen presentation, but involves in immune regulation, inflammatory response and cell signaling. MHC is crucial for stem cell transplant (SCT), and could lead to graft-versus-host disease (GVHD)[1][2].

MHC Isoform Specific Products:

MHC Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P2525
    GAD65 (206-220)
    GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus.
    GAD65 (206-220)
  • HY-P990185
    Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S)
    		Inhibitor
    Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse/rat MHC Class II.
    Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S)
  • HY-P1489B
    OVA Peptide(257-264) acetate salt
    OVA Peptide(257-264) acetate salt is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.
    OVA Peptide(257-264) acetate salt
  • HY-P5966
    Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse
    Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse (MOG (40-54)) is a CD8-related self-antigenic epitope of the myelin oligodendrocyte glycoprotein (MOG) protein and is presented in association with H-2Db.
    Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse
  • HY-P10246
    Hemoglobin (64-76)
    Hemoglobin 64-76 is a T cell inducing determinant, that binds to two different MHC class II molecules in distinct registers and lengths.
    Hemoglobin (64-76)
  • HY-P990140
    Anti-Rat β-2-Microglobulin Antibody (4C9)
    Anti-Rat β-2-Microglobulin Antibody (4C9) is a mouse-derived IgG1 type antibody inhibitor, targeting to rat β-2-Microglobulin.
    Anti-Rat β-2-Microglobulin Antibody (4C9)
  • HY-P3070
    H2-D b restricted epitopes VSV Nucleoprotein (52-59)
    H2-D b restricted epitopes VSV Nucleoprotein (52-59) is a 9-mer peptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). H2-D b restricted epitopes VSV Nucleoprotein (52-59) binds to MHC class I molecules and presents itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs), which can recognize and kill cells expressing the corresponding antigen. H2-D b restricted epitopes VSV Nucleoprotein (52-59) can be used in the development of CTL vaccines against Ebola virus.
    H2-D b restricted epitopes VSV Nucleoprotein (52-59)
  • HY-P5745A
    TYVPANASL TFA
    TYVPANASL TFA is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL TFA can be used to prepare J-LEAPS vaccine.
    TYVPANASL TFA
  • HY-P1745
    InsB (9-23)
    InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7. InsB (9-23) can be used to treat a number of autoimmune related diseases like Type 1 diabetes.
    InsB (9-23)
  • HY-P990184
    Anti-Mouse MHC Class II (βchain) Antibody (KL277)
    		Inhibitor
    Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II.
    Anti-Mouse MHC Class II (βchain) Antibody (KL277)
  • HY-P10382
    M133 peptide
    M133 peptide is a coronavirus-specific CD4 T cell epitope. M133 peptide is immunodominant in mice infected with the neurotropic coronavirus (the JHM strain of mouse hepatitis virus). M133 peptide forms a complex with MHC II molecules, which is recognized by specific TCRs, thereby activating CD4 T cells.
    M133 peptide
  • HY-P5499
    CMV pp65(13-27)
    		Ligand 98.05%
    CMV pp65(13-27) is a biological active peptide. (This peptide is derived from amino acid residues 13 to 27 of the 65k lower matrix phosphoprotein of the human cytomegalovirus. It contains a nine-amino-acid sequence (LGPISGHVL) that matches the consensus binding motif for a major histocompatibility complex H2-Dd T-cell epitope.)
    CMV pp65(13-27)
  • HY-157171
    Ac-YR-NH2
    		Modulator
    Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response.
    Ac-YR-NH2
  • HY-157280
    AdCaPy
    AdCaPy is an MHC II antigen loading catalyst that accelerates the loading of peptide antigens by MHC II. AdCaPy is a useful molecular tool for enhancing immune responses.
    AdCaPy
MHC Isoform Comparison

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