Osteopontin

Osteopontin; Secreted Phosphoprotein 1

Osteopontin (OPN) is a secreted, multifunctional, extracellular matrix (ECM), calcium-binding, glycosylated phosphoprotein that is associated with various normal biological functions and pathological processes. OPN is physiologically produced by a wide range of cells and has been identified in various body fluids, playing a crucial role in bone remodeling and vascularization. OPN is also expressed by multiple immune cells, acting as a chemotactic factor, a mediator of cell activation and cytokine production, and an anti-apoptotic factor, thereby regulating inflammation and immune responses. OPN can be involved in the tumorigenesis of various cancer types, including head and neck squamous cell carcinoma (HNSCC), by promoting cell proliferation, adhesion, invasion, and migration through multiple signaling pathways^[1]^[2].

References:

[1]. El-Zawawy H T, et al. Osteopontin as a marker in thyroid disease: relation to body mass index[J]. Endocrine and Metabolic Science, 2020, 1(1-2): 100049.

[2]. Ghita I, et al. Cytokine profiling in plasma distinguishes the histological inflammatory subtype of head and neck squamous cell carcinoma and a novel regulatory role of osteopontin[J]. Frontiers in oral health, 2022, 3: 993638. [Content Brief]

Osteopontin Inhibitor (1)

Osteopontin Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-146064

OPN expression inhibitor 1	Inhibitor	99.98%
OPN expression inhibitor 1 is an osteopontin (OPN) expression inhibitor. OPN expression inhibitor 1 has potential anti-breast cancer cell metastasis activity and can be used in the study of cancer.

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