2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Kinase
  5. Ser/Thr Kinase Degrader

Ser/Thr Kinase Degrader

Ser/Thr Kinase Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-170574
    CQ627
    		Degrader
    CQ627 is a molecular glue targeting the degradation of RIOK2. It effectively induces the degradation of RIOK2 in the MOLT4 leukemia cell line via the ubiquitin-proteasome system (UPS) by recruiting the E3 ubiquitin ligase RNF126, with a DC50 value of 410 nM. CQ627 dose-dependently induces apoptosis in MOLT4 leukemia cells, blocks their cell cycle in the G2/M phase, and exhibits antiproliferative activities in various cancer cell lines. CQ627 also demonstrates in vivo anticancer activity in a MOLT4 xenograft mouse model.