2. Signaling Pathways
  3. Immunology/Inflammation
  4. Tim3
  5. Tim3 Inhibitor

Tim3 Inhibitor

Tim3 Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-P99827
    Cobolimab
    		Inhibitor
    Cobolimab (TSR-022) is an anti-TIM-3 monoclonal antibody. Cobolimab mediates the internalization of TIM3 with an IC50 value of 0.4464 nM. Cobolimab has potential application in solid tumors and non-small cell lung cancer (NSCLC).
  • HY-155175
    TIM-3-IN-2
    		Inhibitor 99.36%
    TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines.
  • HY-P990004
    Anti-Mouse TIM-3 Antibody (B8.2C12)
    		Inhibitor
    Anti-Mouse TIM-3 Antibody (B8.2C12) is an anti-mouse TIM-3 antibody inhibitor. Anti-Mouse TIM-3 Antibody (B8.2C12) is a rat IgG1κ subtype antibody.