2. Anti-infection
  3. HSV
  4. Tromantadine

Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication.

For research use only. We do not sell to patients.

Tromantadine Chemical Structure

Tromantadine Chemical Structure

CAS No. : 53783-83-8

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Other Forms of Tromantadine:

Tromantadine Related Antibodies

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  • References

  • Customer Review

Description

Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication[1].

IC50 & Target[1]

HSV-1

 

HSV-2

 

In Vitro

Tromantadine inhibits herpes simplex virus type 1 (KOS strain)-induced cytopathic effect and virus replication with limited toxicity to the cells. Vero and HEp-2 cells tolerate up to 2 mg of Tromantadine per 2x106 cells for 24-, 48-, or 96-h incubation periods with little change in cell morphology. Treatment of the cells with 10 to 50 μg of Tromantadine reduces herpes simplex virus-induced cytopathic effect. Treatment with 100 to 500 μg of Tromantadine inhibits herpes simplex virus-induced cytopathic effect and reduces virus production. Complete inhibition of virus production is observed with treatments of 500 μg to 1 mg. The antiherpetic activity of Tromantadine is dependent upon the viral inoculum size and the time of addition of the compound with respect to infection. Virion synthesis and viral polypeptide synthesis are inhibited by addition of Tromantadine at the time of infection or 4 h postinfection[1]. Tromantadine raises the bilayer to hexagonal phase transition temperature of synthetic phosphatidylethanolamines and is less disruptive to phospholipid packing. Tromantadine acts similar to cyclosporin A, previously demonstrated to inhibit viral-induced cell-cell fusion[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tromantadine Related Antibodies
Molecular Weight

280.41

Formula

C16H28N2O2
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(COCCN(C)C)NC1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
Cell Assay
[1]

Confluent monolayers of Vero (2.4x106 per plate) or HEp-2 (1.6x106 per plate) cells are treated with various amounts of Tromantadine 15 min before and then throughout the infection and incubation. The dose of Tromantadine applied, rather than the concentration, is varied since, as for amantadine, the cells concentrate the compound from the medium. For most assays, cells are infected with 6x108 PFU of HSV-1 in 0.5 mL for 1 h at 37°C, and the virus solution is then aspirated off the monolayer and replaced with 2 mL of maintenance medium containing the same amount of the compound. The antiviral activity of the compounds is determined as a reduction in both virally induced cytopathic effect (CPE) and production of extracellular infectious virus 24, 48, and % h postinfection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Tromantadine Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tromantadine53783-83-8HSVHerpes simplex virusHSV-1HSV-2replicationvirusantiherpeticinfectioncytopathictoxicityInhibitorinhibitorinhibit

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HY-U00124
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