Win-62005 

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with K_is of 25 and 26 nM for rat heart and canine aorta, respectively.

Ki: 25 nM (PDE III), 25 nM (PDE III)^[1]

Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with K_i values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

226.23

C₁₂H₁₀N₄O

152633-54-0

O=C1NC2=NC(C)=C(C3=CC=NC=C3)C=C2N1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dundore RL, et al. Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. J Cardiovasc Pharmacol. 1995 Jan;25(1):14-21.  [Content Brief]