(-)-Cevimeline hydrochloride hemihydrate (Synonyms: (-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate)

Cat. No.: HY-76772B Purity: 98.19%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome.

For research use only. We do not sell to patients.

(-)-Cevimeline hydrochloride hemihydrate Chemical Structure

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 1809	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1809	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 672	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 2592	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of (-)-Cevimeline hydrochloride hemihydrate:

(+)-Cevimeline hydrochloride hemihydrate In-stock
Cevimeline In-stock
Cevimeline hydrochloride In-stock
Cevimeline hydrochloride hemihydrate In-stock

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All mAChR Isoform Specific Products:

View All Isoforms

mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Biological Activity
Purity & Documentation
Customer Review

Description

(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. IC50 value: Target: mAChR The general pharmacol. properties of this drug on the gastrointestinal, urinary, and reproductive systems and other tissues were investigated in mice, rats, guinea pigs, rabbits, and dogs. The in vitro metab. of SNI-2011 was also evaluated with rat and dog liver microsomes. After oral administration, plasma concns. of SNI-2011 reached to Cmax within 1 h in both species, suggesting that SNI-2011 was quickly absorbed, and then decreased with a t1/2 of 0.4-1.1 h. The bioavailability was 50% and 30% in rats and dogs, resp. Major metabolites in plasma were both S- and N-oxidized metabolites in rats and only N-oxidized metabolite in dogs, indicating that a large species difference was obsd. in the metab. of SNI-2011. Sex difference was also obsd. in the pharmacokinetics of SNI-2011 in rats, but not in dogs. In the in vitro study, chem. inhibition and pH-dependent studies revealed that the sulfoxidn. and N-oxidn. of SNI-2011 were mediated by cytochrome P 450 (CYP) and flavin-contg. monooxygenase (FMO), resp., in both species. In addn., CYP2D and CYP3A were mainly responsible for the sulfoxidn. in rat liver microsomes.

Molecular Weight

244.78

Formula

C₁₀H₁₇NOS.HCl.1/2H₂O

Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@@H](SC1)O[C@@]21CN3CCC2CC3.Cl.[0.5H2O]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (408.53 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0853 mL	20.4265 mL	40.8530 mL
5 mM	0.8171 mL	4.0853 mL	8.1706 mL
10 mM	0.4085 mL	2.0427 mL	4.0853 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.19%

Select Batch:

Data Sheet (248 KB) SDS (252 KB)

COA (251 KB) RP-HPLC (138 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.0853 mL	20.4265 mL	40.8530 mL	102.1325 mL
	5 mM	0.8171 mL	4.0853 mL	8.1706 mL	20.4265 mL
	10 mM	0.4085 mL	2.0427 mL	4.0853 mL	10.2133 mL
	15 mM	0.2724 mL	1.3618 mL	2.7235 mL	6.8088 mL
	20 mM	0.2043 mL	1.0213 mL	2.0427 mL	5.1066 mL
	25 mM	0.1634 mL	0.8171 mL	1.6341 mL	4.0853 mL
	30 mM	0.1362 mL	0.6809 mL	1.3618 mL	3.4044 mL
	40 mM	0.1021 mL	0.5107 mL	1.0213 mL	2.5533 mL
	50 mM	0.0817 mL	0.4085 mL	0.8171 mL	2.0427 mL
	60 mM	0.0681 mL	0.3404 mL	0.6809 mL	1.7022 mL
	80 mM	0.0511 mL	0.2553 mL	0.5107 mL	1.2767 mL
	100 mM	0.0409 mL	0.2043 mL	0.4085 mL	1.0213 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(-)-Cevimeline hydrochloride hemihydrate Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Cevimeline hydrochloride hemihydrate(-)-SNI-2011(-)-AF102B hydrochloride hemihydratemAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks