2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Dihomo-γ-linolenic acid

Dihomo-γ-linolenic acid  (Synonyms: DGLA; all-cis-8,11,14-Eicosatrienoic acid)

Cat. No.: HY-A0143 Purity: ≥99.0%
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Handling Instructions Technical Support

Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.

For research use only. We do not sell to patients.

Dihomo-γ-linolenic acid Chemical Structure

Dihomo-γ-linolenic acid Chemical Structure

CAS No. : 1783-84-2

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5 mg (326.28 mM * 50 μL in Ethanol) In-stock

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Based on 3 publication(s) in Google Scholar

Other Forms of Dihomo-γ-linolenic acid:

Dihomo-γ-linolenic acid Related Antibodies

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Description

Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
RBL-2H3 IC50
> 50 μM
Compound: 4
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
[PMID: 31618024]
In Vitro

Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages[2].
Dihomo-γ-linolenic acid (50?μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727[2].
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages[2].
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation[2].
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages[2].
Dihomo-γ-linolenic acid modulates mitochondrial respiration[2].
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dihomo-γ-linolenic acid Related Antibodies

Western Blot Analysis[2]

Cell Line: THP-1 macrophages
Concentration: 50 μM (pre-treated)
Incubation Time: 24 hours
Result: Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727.
In Vivo

Dihomo-γ-linolenic acid (8?mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (48 four-week old)[3]
Dosage: 8 mg/mouse
Administration: Oral gavage, twice a week, for 35 days
Result: Suppressed metastasis potential in D5D-KD tumors.
Molecular Weight

306.48

Formula

C20H34O2
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥99.0%

SDS (393 KB)

COA (237 KB)

Handling Instructions (2659 KB)
References
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Dihomo-γ-linolenic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihomo-γ-linolenic acid1783-84-2DGLA all-cis-8,11,14-Eicosatrienoic acidEndogenous Metaboliteanti-inflammatoryanti-proliferativefattyacidatherosclerosisInhibitorinhibitorinhibit

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