2. GPCR/G Protein
  3. Endothelin Receptor
  4. A-127722

A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ETA selective endothelin receptor (ET receptor) antagonist with IC50 value of 0.36 nM.

For research use only. We do not sell to patients.

A-127722 Chemical Structure

A-127722 Chemical Structure

CAS No. : 195704-72-4

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A-127722 Related Antibodies

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Description

A-127722 is A 2, 4-dialarylpyrrolidine-3-carboxylic acid ETA selective endothelin receptor (ET receptor) antagonist with IC50 value of 0.36 nM[1].

Cellular Effect
Cell Line Type Value Description References
Pituitary gland cell IC50
0.4 nM
Compound: 13
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
[PMID: 9022798]
Molecular Weight

510.62

Formula

C29H38N2O6
CAS No.
SMILES

O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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A-127722 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-127722195704-72-4A127722A 127722Endothelin ReceptorETAntagonistBioavailabilityInhibitorinhibitorinhibit

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HY-114674
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