1. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  2. Histamine Receptor
  3. A-943931

A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy.

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A-943931 Chemical Structure

A-943931 Chemical Structure

CAS No. : 1027330-97-7

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Description

A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy[1][2].

IC50 & Target[1]

Human H4 Receptor

4.6 nM (Ki)

Rat H4 receptor

3.8 nM (Ki)

In Vivo

A-943931 shows anti-inflammatory activity in zymosan-induced peritonitis in mice with the ED50s of 34, 33 µmol/kg for s.c. and i.p., respectively[2].
A-943931 (10, 30, 100 µmol/kg; i.p.) shows antinociceptive efficacy in inflammatory pain and neuropathic pain model in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats (carrageenan-induced inflammatory pain and spinal nerve ligation model of neuropathic pain)[2]
Dosage: 10, 30, 100 µmol/kg
Administration: I.p.
Result: Showed antinociceptive efficacy in an inflammatory pain model in rat at an ED50 value of 72 µmol/kg, ip, and in a neuropathic pain model at an ED50 value of 100 µmol/kg, ip.
Molecular Weight

295.38

Formula

C17H21N5

CAS No.
SMILES

N[C@@H](C1)CCN1C2=C3CCCC4=CC=CC=C4C3=NC(N)=N2

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Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
A-943931
Cat. No.:
HY-113936
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