AC-386

Cat. No.: HY-143463: FAQs
Data Sheet Handling Instructions Technical Support

AC-386 is a highly potent c-Met inhibitor with IC₅₀ value of 7.42 nM. AC-386 has antiproliferative activities against certain cancer cell lines. AC-386 can be used for researching anti-cancer resistance.

For research use only. We do not sell to patients.

AC-386 Chemical Structure

CAS No. : 1902910-89-7

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.12 μM Compound: AC-386	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 32738414]
HCT-116	IC₅₀	0.37 μM Compound: AC-386	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 32738414]
MCF7	IC₅₀	0.63 μM Compound: AC-386	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay	[PMID: 32738414]

In Vitro

AC-386 (0-20 μM; 72 hours) exhibits antiproliferative activities against HCT-116, MCF-7 and A549^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:	HCT-116, MCF-7 and A549^[1]
Concentration:	0-20 μM
Incubation Time:	72 hours
Result:	Exhibited antiproliferative activities against HCT-116, MCF-7 and A549 with IC₅₀s of 0.37 ± 0.02 μM, 0.63 ± 0.05 μM, 1.12 ± 0.10 μM in HCT-116, MCF-7 and A549, respectively.

Molecular Weight

639.67

Formula

C₃₅H₃₄FN₅O₆

CAS No.

1902910-89-7

SMILES

O=C(C1=NN(C2=CC=CC=C2)C=C(C)C1=O)NC3=CC=C(OC4=CC=NC5=CC(OCCCN6CCOCC6)=C(OC)C=C45)C(F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hu H, Chen F, Dong Y, et al. Discovery of Novel c-Mesenchymal-Epithelia transition factor and histone deacetylase dual inhibitors. Eur J Med Chem. 2020;204:112651. [Content Brief]

AC-386 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC-3861902910-89-7AC386AC 386c-Met/HGFRAnticancerAntiproliferative activitiesHCT-116MCF-7A549Inhibitorinhibitorinhibit

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