2. Anti-infection
  3. HSV Antibiotic
  4. Acyclovir monophosphate

Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity.

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Acyclovir monophosphate Chemical Structure

Acyclovir monophosphate Chemical Structure

CAS No. : 66341-16-0

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Other Forms of Acyclovir monophosphate:

Acyclovir monophosphate Related Antibodies

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Description

Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity[1][2].

Cellular Effect
Cell Line Type Value Description References
Vero CC50
> 2000 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
[PMID: 22954898]
Vero EC50
20 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
[PMID: 22954898]
Vero EC50
41 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
[PMID: 22954898]
Molecular Weight

305.18

Formula

C8H12N5O6P
CAS No.
SMILES

O=C1N=C(NC2=C1N=CN2COCCOP(O)(O)=O)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Acyclovir monophosphate Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acyclovir monophosphate66341-16-0HSVAntibioticHerpes simplex virusnucleoside analogDNA synthesisantitumorInhibitorinhibitorinhibit

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Acyclovir monophosphate
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HY-17422B
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