Adatanserin hydrochloride  (Synonyms: WY-50324 hydrochloride; SEB-324 hydrochloride)

Adatanserin hydrochloride is a high affinity, selective and partial agonist for the 5-HT_1A receptor with a K_i of 1 nM. Adatanserin hydrochloride is a moderate affinity 5-HT₂ receptor antagonist with a K_i of 73 nM. Adatanserin hydrochloride shows significant anxiolytic and antidepressant activity in an animal conflict model^[1][2].

405.96

C₂₁H₃₂ClN₅O

144966-96-1

O=C(C1(C2)CC3CC2CC(C3)C1)NCCN4CCN(C5=NC=CC=N5)CC4.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. M A Abou-Gharbia, et al. Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents.  [Content Brief]

  [2]. A Singh, et al. Antidepressant-like activity of compounds with varying efficacy at 5-HT1A receptors. Neuropharmacology. 1993 Apr;32(4):331-40.  [Content Brief]