2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor mAChR
  4. ADS1017

ADS1017 is the antagonist for histamine receptor and muscarinic receptor, that exhibits good affinities to hH3R, hH4R, hM2R and hM4R with pKi of 6.8, 5.5, 7.4 and 7.2. ADS1017 exhibits analgesic and anti-allodynic efficacy in mice Capsaicin (HY-10448)-or Oxaliplatin (HY-17371)-induced pain models.

For research use only. We do not sell to patients.

ADS1017 Chemical Structure

ADS1017 Chemical Structure

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ADS1017 Related Antibodies

Top Publications Citing Use of Products

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

ADS1017 is the antagonist for histamine receptor and muscarinic receptor, that exhibits good affinities to hH3R, hH4R, hM2R and hM4R with pKi of 6.8, 5.5, 7.4 and 7.2. ADS1017 exhibits analgesic and anti-allodynic efficacy in mice Capsaicin (HY-10448)-or Oxaliplatin (HY-17371)-induced pain models[1].

Molecular Weight

479.70

Formula

C29H45N5O
SMILES

NC(N(CCCCN1CCN(CCCCCCCOC2=CC=CC=C2)CC1)CC3=CC=CC=C3)=N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ADS1017 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ADS1017ADS 1017ADS-1017Histamine ReceptormAChRMuscarinic acetylcholine receptorantiallodynicantinociceptiveantihyperalgesicInhibitorinhibitorinhibit

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