2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Alloc-Val-Ala-pAB

Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

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Alloc-Val-Ala-pAB Chemical Structure

Alloc-Val-Ala-pAB Chemical Structure

CAS No. : 1343407-91-9

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Alloc-Val-Ala-pAB Related Antibodies

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Description

Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

Molecular Weight

377.43

Formula

C19H27N3O5
CAS No.
Appearance

Solid

SMILES

OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCC=C)=O)C(C)C)=O)C)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Alloc-Val-Ala-pAB Related Classifications

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Keywords:

Alloc-Val-Ala-pAB1343407-91-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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