2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Alloc-Val-Ala-pAB

Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

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Alloc-Val-Ala-pAB Chemical Structure

Alloc-Val-Ala-pAB Chemical Structure

CAS No. : 1343407-91-9

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Alloc-Val-Ala-pAB Related Antibodies

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Description

Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

Molecular Weight

377.43

Formula

C19H27N3O5
CAS No.
Appearance

Solid

SMILES

OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCC=C)=O)C(C)C)=O)C)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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Alloc-Val-Ala-pAB Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alloc-Val-Ala-pAB1343407-91-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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