AM-7209

Cat. No.: HY-12941: FAQs
Data Sheet Handling Instructions

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AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a K_d of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC₅₀ of 1.6 nM. AM-7209 shows antitumor activities.

For research use only. We do not sell to patients.

AM-7209 Chemical Structure

CAS No. : 1623432-51-8

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	> 25 μM Compound: 25, AM-7209	Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay	[PMID: 25384157]
HCT-116	IC₅₀	2 nM Compound: 25, AM-7209	Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay	[PMID: 25384157]
SJSA-1	ED₅₀	2.6 mg/kg Compound: 25, AM-7209	Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days	[PMID: 25384157]

Molecular Weight

747.70

Formula

C₃₇H₄₁Cl₂FN₂O₇S

CAS No.

1623432-51-8

SMILES

O=C(O)C1=CC=C(NC(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)=O)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yosup Rew, et al. Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction. J Med Chem. 2014 Dec 26;57(24):10499-511. [Content Brief]

AM-7209 Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-72091623432-51-8AM7209AM 7209MDM-2/p53MDM2-p53 interaction inhibitorantitumor activitiesInhibitorinhibitorinhibit

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