2. Apoptosis
  3. MDM-2/p53
  4. AM-7209

AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities.

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AM-7209 Chemical Structure

AM-7209 Chemical Structure

CAS No. : 1623432-51-8

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AM-7209 Related Antibodies

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Description

AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
> 25 μM
Compound: 25, AM-7209
Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay
Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay
[PMID: 25384157]
HCT-116 IC50
2 nM
Compound: 25, AM-7209
Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay
Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay
[PMID: 25384157]
SJSA-1 ED50
2.6 mg/kg
Compound: 25, AM-7209
Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days
Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days
[PMID: 25384157]
Molecular Weight

747.70

Formula

C37H41Cl2FN2O7S
CAS No.
SMILES

O=C(O)C1=CC=C(NC(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)=O)C=C1OC
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Purity & Documentation
References
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AM-7209 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM-72091623432-51-8AM7209AM 7209MDM-2/p53MDM2-p53 interaction inhibitorantitumor activitiesInhibitorinhibitorinhibit

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