Ambroxol (acefylline)  (Synonyms: NA-872 (acefylline); Acebrophylline)

Ambroxol (NA-872) acefylline, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol acefylline is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol acefylline induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research^[1][2].

616.30

C₂₂H₂₈Br₂N₆O₅

96989-76-3

OC(CN1C2=C(N=C1)N(C(N(C2=O)C)=O)C)=O.O[C@H](CC3)CC[C@@H]3NCC4=C(C(Br)=CC(Br)=C4)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218.  [Content Brief]

  [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775.  [Content Brief]