AMG131 benzenesulfonate  (Synonyms: INT131 benzenesulfonate)

AMG131 (INT131) (benzenesulfonate) is a potent non-thiazolidinedione (TZD) selective peroxisome proliferator-activated receptor γ modulator (SPPARM). AMG131 (benzenesulfonate) binds to PPARγ within the same binding pocket as the TZDs, but occupies a unique space in the pocket and contacts the receptor at distinct points from the TZDs. AMG131 (benzenesulfonate) is promising for research of type-2 diabetes mellitus^[1][2][3].

672.38

C₂₇H₁₈Cl₄N₂O₆S₂

849738-78-9

O=S(O)(C1=CC=CC=C1)=O.O=S(NC2=CC(Cl)=C(C(Cl)=C2)OC3=CN=C4C=CC=CC4=C3)(C5=CC=C(C=C5Cl)Cl)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Linda S Higgins,et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906.  [Content Brief]

  [2]. Alykhan Motani, et al. INT131: a selective modulator of PPAR gamma. J Mol Biol. 2009 Mar 13;386(5):1301-11.  [Content Brief]

  [3]. Higgins LS, et al. The Development of INT131 as a Selective PPARgamma Modulator: Approach to a Safer Insulin Sensitizer. PPAR Res. 2008;2008:936906.  [Content Brief]