Amino-PEG4-bis-PEG3-methyltetrazine

Cat. No.: HY-130970: FAQs
Data Sheet Handling Instructions

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Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

For research use only. We do not sell to patients.

Amino-PEG4-bis-PEG3-methyltetrazine Chemical Structure

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Purity & Documentation
References
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Description

Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1]. Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1255.42

Formula

C₅₈H₉₀N₁₄O₁₇

SMILES

NCCOCCOCCOCCOCCC(NC(COCCC(NCCOCCOCCOCCNC(CC1=CC=C(C2=NN=C(C)N=N2)C=C1)=O)=O)COCCC(NCCOCCOCCOCCNC(CC3=CC=C(C4=NN=C(C)N=N4)C=C3)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]