Anti-neuroinflammation agent 1 

Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype^[1].

Anti-neuroinflammation agent 1 (BMP 29) shows more potent anti-neuroinflammatory activity and no toxicity to BV2 microglia cells in vitro. Anti-neuroinflammation agent 1 significantly reduces the number of M1 phenotype of microglia cells, but significantly increases the number of M2 phenotype of microglia cells in lipopolysaccharide (LPS)-induced BV2 microglia cells. Anti-neuroinflammation agent 1 significantly reduces the secretion of inflammatory cytokines (IL-18, IL-1β, TNF-α), but increases the secretion of anti-inflammatory cytokines (IL-10) from LPS-induced BV2 microglia cells. Also, Anti-neuroinflammation agent 1 inhibits the NOD-like receptor NLRP3 inflammasome formation, and down-regulated the expression of M2 isoform of pyruvate kinase in LPS-induced BV2 microglia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In mice, Anti-neuroinflammation agent 1 (BMP 29) reduces the neuroinflammation in cuprizone-induced inflammatory and demyelinating mice by reducing the expression of inducible nitric-oxide synthase, but increased the expression of CD206^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

523.86

C₂₂H₂₀ClF₆N₃O₃

2968412-77-1

COC1=CC2=C(C(OC)=C1)C3=C(CCO2)C(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)N=C(N)N3.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang Yang, et al. Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization. Eur J Med Chem. 2023 Jul 27;259:115688.  [Content Brief]