Antibacterial agent 115

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Antibacterial agent 115 (Compound 10) is an orally active antibacterial and anti-inflammatory agent.

For research use only. We do not sell to patients.

Antibacterial agent 115 Chemical Structure

CAS No. : 2259732-60-8

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Biological Activity
Purity & Documentation
References
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Description

Antibacterial agent 115 (Compound 10) is an orally active antibacterial and anti-inflammatory agent^[1].

In Vitro

Antibacterial agent 115 (Compound 10) shows antibacterial activity with MIC values of both 2.72 μg/mL against Staphylococcus aureussubsp.aureus (ATCC 29213), Staphylococcus epidermidis (ATCC 12228) and Staphylococcus aureus (ATCC 6538)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 115 (Compound 10) (0-40 mg/kg; i.g.; seven consecutive days) shows anti-inflammatory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Kunming female mice (body weight 18–22 g), 12-O-tetradecylphorbol-13- acetate (TPA) induced ear edema mice model^[1].
Dosage:	10, 20, 40 mg/kg
Administration:	Gavage, seven consecutive days
Result:	Inhibited swelling of mouse ears and inhibited the expression of TNF-α, IL-1β and p65.

Molecular Weight

544.77

Formula

C₃₅H₄₈N₂O₃

CAS No.

2259732-60-8

SMILES

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](C)(CC4)C(O)=O)C)C)([H])[C@@]5([C@@](C(C)(C(/C(C5)=C\C6=NC=CN=C6)=O)C)([H])CC1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang Y, et al. Synthesis, anti-microbial and anti-inflammatory activities of 18β-glycyrrhetinic acid derivatives. Bioorg Chem. 2020 Aug;101:103985. [Content Brief]