2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Antibacterial agent 124

Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS).

For research use only. We do not sell to patients.

Antibacterial agent 124 Chemical Structure

Antibacterial agent 124 Chemical Structure

CAS No. : 2304448-00-6

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Antibacterial agent 124 Related Antibodies

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Description

Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS)[1].

IC50 & Target

IC50: 0.18 μM (SaProRS)[1]
Kd: 30.3 nM (SaProRS)[1]
In Vitro

Antibacterial agent 124 (Compound 3) shows antibacterial activity with MICs of 1, 1, 4, 1, 1, 2 and 4 μg/mL against E. coli (ATCC25922), S. flexneri (CMCC51572), S. typhi (CMCC50094), MRSA252, MRSA R3708, S. aureus ATCC29213, S. aureus ATCC25923, respectively. And the CC50 to HepG2 is 4.32 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 124 Related Antibodies
Molecular Weight

337.78

Formula

C16H17ClFN3O2
CAS No.
SMILES

O=C(CN1C=NC2=CC(Cl)=C(C=C2C1=O)F)C[C@@H]3CCCCN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antibacterial agent 124 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 1242304448-00-6Antibacterial agent124Antibacterial agent-124DNA/RNA Synthesisprolyl-tRNA synthetaseProRSStaphylococcus aureusInhibitorinhibitorinhibit

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