Antibacterial agent 139 

Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA, anti-VISA, and anti-LRSE activities. Antibacterial agent 139 depolarizes the bacterial cell membrane^[1].

Antibacterial agent 139 (Compound 44) (18 h) inhibits the growth of biofilm-forming S. aureus and S. epidermidis strains, with MIC values less than 12.5 μg/mL^[1].
Antibacterial agent 139 (24 h) shows citotoxicity against lung and skin fibroblast cell lines (MCR-5 and BJ), with IC₅₀s of 12.5 and >25 μg/mL^[1].
Antibacterial agent 139 (60 min) is metabolically stable in rat liver microsomes, displaying a low Clearance value (8.94 μL/min/mg)^[1].
Antibacterial agent 139 depolarizes the bacterial cell membrane^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

532.00

C₂₈H₂₉ClF₃N₃O₂

O=C(NC1CCN(CC1)CCC(C2=CC=CC=C2)OC3=CC=CC(C(F)(F)F)=C3)NC4=CC=CC(Cl)=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Canale V, et al. Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria. Eur J Med Chem. 2023 May 5;251:115224.  [Content Brief]