1. Anti-infection
  2. Bacterial
  3. Antibacterial agent 140 chloride

Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride  also possessed robust antibacterial activity for G+ under light irradiation.

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Antibacterial agent 140 chloride Chemical Structure

Antibacterial agent 140 chloride Chemical Structure

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Description

Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride  also possessed robust antibacterial activity for G+ under light irradiation[1].

In Vitro

Antibacterial agent 140 chloride(0.1-5 μg/mL;1 h) exhibits a dose-dependent viability from 78% to 0% in the dark, demonstrating the dark toxicity of Ru2 toward S. aureus[1].
Antibacterial agent 140 chloride(0.1-5 μg/mL;1 h) displays an obvious dose-dependent and time-dependent killing efficiencies upon 120s light irradiation, Ru2 almost completely inhibited the growth of S. aureus at a very low concentration upon light irradiation[1].
Antibacterial agent 140 chloride(0-32 μM;1 h)exhibits more than 80% of HeLa cells remained alive after incubation with < 32 μM in the dark. It leads to >73% of HeLa cells alive at concentrations of ≤32 μM under the light irradiation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antibacterial agent 140 chloride(20 μg/mL/50 μL; 1-10 days) displays a remarkable reduction in wound size under light irradiation, it results in almost complete wound healing after 7 day in female Kunming mice after S. aureus. infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Kunming mice (5-6 weeks old) mice model with skin infected by S. aureus.[1]
Dosage: 50 μL (20 μg/mL)
Administration: 50 μL (20 μg/mL); skin application; 1-10 days
Result: 99.50% of the infected wound areas were healed after 10 days under Ru2/light treatment.
Exhibited photodynamic antibacterial therapeutic efficacy.
Molecular Weight

1162.10

Formula

C61H44Cl2N8Ru2-

SMILES

CC(C)(C1=CC=C(C=C1)N2C(C3=CC4=C(C5=C3C=CC=C5)C=CC=C4)=NC6=C2C7=C8C9=C6C=CC=[N]9[Ru]%10%11([N]8=CC=C7)([N]%12=C%13C(C=CC%14=CC=C[N]%11=C%14%13)=CC=C%12)([Ru+])[N]%15=C%16C(C=CC%17=CC=C[N]%10=C%17%16)=CC=C%15)C.[Cl-].[Cl-]

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Purity & Documentation
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Antibacterial agent 140 chloride Related Classifications

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Product Name:
Antibacterial agent 140 chloride
Cat. No.:
HY-149801A
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