NRG3 Antibody (YA1432)

NRG3 Antibody (YA1432) is a biotin-conjugated non-conjugated IgG antibody, targeting NRG3, with a predicted molecular weight of 78 kDa (observed band size: 55 kDa). NRG3 Antibody (YA1432) can be used for WB experiment in human, rat background.

The related gene is a member of the neuregulin related gene family. The related gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. The related gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryorelated genesis. Linkage studies have implicated The related gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.

10718

Predicted band size: 78 kDa; Observed band size: 55 kDa

Affinity Purified

Non-conjugated

Unmodified

Neuroscience

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Rat

P56975

WB: 1/500-1/1000

WB

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic peptide of human NRG3