Phospho-p27 Kip 1 (Ser10) Antibody (YA1494)

Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1494), targeting Phospho-p27 Kip 1 (Ser10), with a predicted molecular weight of 22 kDa (observed band size: 27 kDa). Phospho-p27 Kip 1 (Ser10) Antibody (YA1494) can be used for WB, IHC-P, IP experiment in human, mouse, rat background.

The related gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of The protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in The related gene are associated with multiple endocrine neoplasia type IV (MEN4).

1027

Predicted band size: 22 kDa; Observed band size: 27 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

P46527

WB: 1/500-1/1000;IHC: 1/50-1/100;IP: 1/20

WB, IHC-P, IP

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic phosphopeptide corresponding to residues surrounding Ser10 of human p27 KIP 1