Phospho-Rad17 (Ser656) Antibody (YA2640)

Phospho-Rad17 (Ser656) Antibody (YA2640) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2640), targeting Phospho-Rad17 (Ser656), with a predicted molecular weight of 77 kDa (observed band size: 80 kDa). Phospho-Rad17 (Ser656) Antibody (YA2640) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

The protein encoded by The related gene is highly similar to the related gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint related gene required for cell cycle arrest and DNA damage repair in response to DNA damage. The protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. The protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. The protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of The protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of The related gene, which encode four distinct protein isoforms, have been reported. Two pseudorelated genes, located on chromosomes 7 and 13, have been identified.

5884

Predicted band size: 77 kDa; Observed band size: 80 kDa

Affinity Purified

Non-conjugated

Phosphorylated

Cell Biology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

O75943

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200

WB, IHC-F, IHC-P, ICC/IF

Liquid

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthetic phosphopeptide corresponding to residues surrounding Ser656 of human Rad17