TAB1 Antibody (YA1951)

TAB1 Antibody (YA1951) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1951), targeting TAB1, with a predicted molecular weight of 55 kDa (observed band size: 60 kDa). TAB1 Antibody (YA1951) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

The protein encoded by The related gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. The protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of The protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that The protein may function as a mediator between TGF beta receptors and TAK1. The protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

10454

Predicted band size: 55 kDa; Observed band size: 60 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Signal Transduction

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human, Mouse, Rat

Q15750

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200;IP: 1/40;FC: 1/50-1/100

WB, IHC-P, ICC/IF, IP, FC

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human TAB1