Toll-Like Receptor 7 Antibody (YA2514)

Toll-Like Receptor 7 Antibody (YA2514) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2514), targeting Toll-Like Receptor 7, with a predicted molecular weight of 121 kDa (observed band size: 140 kDa). Toll-Like Receptor 7 Antibody (YA2514) can be used for WB, IHC-P experiment in human background.

The protein encoded by The related gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in The way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. The related gene is predominantly expressed in lung, placenta, and spleen, and is phylorelated genetically related and lies in close proximity to another family member, TLR8, on chromosome X.

51284

Predicted band size: 121 kDa; Observed band size: 140 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

Q9NYK1

WB: 1/500-1/1000;IHC: 1/50-1/100

WB, IHC-P

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human TLR7