2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. Anticancer agent 231

Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy.

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Anticancer agent 231 Chemical Structure

Anticancer agent 231 Chemical Structure

CAS No. : 128519-30-2

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Anticancer agent 231 Related Antibodies

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Description

Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy[1].
IC50 & Target

ERK1

 

ERK2

 

In Vitro

Anticancer agent 231 (Compound P5) has good cytotoxicity and inhibits TNBC cells’ viability[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 14 days; 1, 2, 4 μM, 8 days) decreases the proliferation capacity of Hs578T cells and MDA MB-231 cells[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 12 h) decreases the migration ability of Hs578T cells[1].
Anticancer agent 231 (Compound P5) (1, 2 μM) inhibits tumor stemness and enhances the sensitivity of TNBC cells to paclitaxel[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM; 5, 10, 20 μM) inhibits TNBC cells by targeting the EGFR-ERK 1/2 axis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 231 Related Antibodies

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Viability Assay[1].

Cell Line: Hs578T cell, MDA MB 231 cell
Concentration: 0-40 μM
Incubation Time: 48 h
Result: Exhibited the most cytotoxic effect against Hs578T cells and MDA MB 231 cells

Cell Proliferation Assay[1].

Cell Line: Hs578T cell
Concentration: 1, 2, 4 μM
Incubation Time: 14 days
Result: Inhibited the colony formation of Hs578T cells

Cell Proliferation Assay[1].

Cell Line: MDA MB 231 cell
Concentration: 5, 10, 20 μM
Incubation Time: 8 days
Result: Inhibited the colony formation of MDA MB 231 cells

Cell Migration Assay [1].

Cell Line: Hs578T cell
Concentration: 1, 2, 4 μM
Incubation Time: 12 h
Result: Inhibited the migration ability of Hs578T cells

Western Blot Analysis[1].

Cell Line: Hs578T cell, MDA MB 231 cell
Concentration: 1, 2, 4 μM; 5, 10, 20 μM
Incubation Time: 48 h
Result: Reduced the EGFR expression level in Hs578T and MDA MB 231 cells and deactivated the EGFR in MDA MB 231 cells
Molecular Weight

375.89

Formula

C23H22ClN3
CAS No.
SMILES

ClC1=CC=C(C2=NN(C3=CC=CC=C3)C(C4=CC=C(N(C)C)C=C4)C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 231 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 231128519-30-2Anticancer agent231Anticancer agent-231ERKExtracellular signal regulated kinasesN-phenyl pyrazolineTNBCHs578T cellMDA MB 231 cellInhibitorinhibitorinhibit

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