2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. Anticancer agent 231

Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy.

For research use only. We do not sell to patients.

Anticancer agent 231 Chemical Structure

Anticancer agent 231 Chemical Structure

CAS No. : 128519-30-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Anticancer agent 231 Related Antibodies

Top Publications Citing Use of Products

View All ERK Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Anticancer agent 231 (Compound P5) is a tyrosine protein kinase inhibitor with a IC50 value of 3.95 μM. Anticancer agent 231 inhibits the cell viability, cell proliferation, cell migration and cancer dryness of triple negative breast cancer (TNBC) cells by targeting EGFR-ERK 1/2 signaling pathway, and is expected to play an important role in the field of TNBC disease therapy[1].
IC50 & Target

ERK1

 

ERK2

 

In Vitro

Anticancer agent 231 (Compound P5) has good cytotoxicity and inhibits TNBC cells’ viability[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 14 days; 1, 2, 4 μM, 8 days) decreases the proliferation capacity of Hs578T cells and MDA MB-231 cells[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM, 12 h) decreases the migration ability of Hs578T cells[1].
Anticancer agent 231 (Compound P5) (1, 2 μM) inhibits tumor stemness and enhances the sensitivity of TNBC cells to paclitaxel[1].
Anticancer agent 231 (Compound P5) (1, 2, 4 μM; 5, 10, 20 μM) inhibits TNBC cells by targeting the EGFR-ERK 1/2 axis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 231 Related Antibodies

Cell Line:
Concentration:
Incubation Time:
Result:

Cell Viability Assay[1].

Cell Line: Hs578T cell, MDA MB 231 cell
Concentration: 0-40 μM
Incubation Time: 48 h
Result: Exhibited the most cytotoxic effect against Hs578T cells and MDA MB 231 cells

Cell Proliferation Assay[1].

Cell Line: Hs578T cell
Concentration: 1, 2, 4 μM
Incubation Time: 14 days
Result: Inhibited the colony formation of Hs578T cells

Cell Proliferation Assay[1].

Cell Line: MDA MB 231 cell
Concentration: 5, 10, 20 μM
Incubation Time: 8 days
Result: Inhibited the colony formation of MDA MB 231 cells

Cell Migration Assay [1].

Cell Line: Hs578T cell
Concentration: 1, 2, 4 μM
Incubation Time: 12 h
Result: Inhibited the migration ability of Hs578T cells

Western Blot Analysis[1].

Cell Line: Hs578T cell, MDA MB 231 cell
Concentration: 1, 2, 4 μM; 5, 10, 20 μM
Incubation Time: 48 h
Result: Reduced the EGFR expression level in Hs578T and MDA MB 231 cells and deactivated the EGFR in MDA MB 231 cells
Molecular Weight

375.89

Formula

C23H22ClN3
CAS No.
SMILES

ClC1=CC=C(C2=NN(C3=CC=CC=C3)C(C4=CC=C(N(C)C)C=C4)C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Anticancer agent 231 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 231128519-30-2Anticancer agent231Anticancer agent-231ERKExtracellular signal regulated kinasesN-phenyl pyrazolineTNBCHs578T cellMDA MB 231 cellInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Anticancer agent 231
Cat. No.:
HY-162575
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.