Anticancer agent 48 

Anticancer agent 48 (compound 48) is a broad spectrum anticancer agent. Anticancer agent 48 inhibits tubulin polymerization. Anticancer agent 48 shows antiproliferative activity. Anticancer agent 48 shows antitumor activity in vivo. Anticancer agent 48 has the potential for the research of solid and hematological tumors^[1].

Anticancer agent 48 (compound 48) inhibits tubulin polymerization and MCF-7 cancer cell growth with IC₅₀s of 0.47 µM and 14 nM, respectively^[1].
Anticancer agent 48 shows antiproliferative activity with IC₅₀s of 8, 10, 12, 14, 16 nM for KU812, LAMA84-S, LAMA84-R, KBM5-WT, KBM5-T315I cells, respectively^[1].
Anticancer agent 48 shows growth inhibition with IC₅₀s of 12, 31, 37, 221, 56, 27, 51, 48, 28, 12 nM for U343G, U87MG, T98G, SK-N-BE, SK-N-BE(2)-C, HT29, HCT116, SW480, SW620, T24 cell, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 48 (20 mg/kg; i.p.; every 2 days for 40 days) shows antitumor effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

443.49

C₂₆H₂₅N₃O₄

2395009-13-7

COC1=CC(C(C2=CN(C=C2C3=CC=C(C=C3)N)C4=CC=CC(N)=C4)=O)=CC(OC)=C1OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Puxeddu M, et al. Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies. Eur J Med Chem. 2020 Jan 1;185:111828.  [Content Brief]