Anticancer agent 52

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Anticancer agent 52 is a potent anticancer agent. Anticancer agent 52 shows in vitro cytotoxicity. Anticancer agent 52 induces apoptosis. Anticancer agent 52 shows antitumor effect. Anticancer agent 52 has the potential for the research of bladder cancer.

For research use only. We do not sell to patients.

Anticancer agent 52 Chemical Structure

CAS No. : 2388983-64-8

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
5637	GI₅₀	200 μM Compound: TPP1	Growth inhibition of human 5637 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human 5637 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
RT-112	GI₅₀	200 μM Compound: TPP1	Growth inhibition of human RT112 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human RT112 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
RT-4	GI₅₀	150 μM Compound: TPP1	Growth inhibition of human RT4 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human RT4 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
SW780	GI₅₀	200 μM Compound: TPP1	Growth inhibition of human SW780 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human SW780 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
TCC-SUP	GI₅₀	240 μM Compound: TPP1	Growth inhibition of human TCCSUP cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human TCCSUP cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
UMUC3	GI₅₀	80 μM Compound: TPP1	Growth inhibition of human UM-UC-3 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human UM-UC-3 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]

In Vitro

Anticancer agent 52 (compound TPP1) (0-2048 µM) shows cytotoxicity with IC₅₀s of 200, 200, 150, 200, 240, 80 µM for 5637, RT112, RT4, SWT80, TCCSUP, UMUC3 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	RT112 cells
Concentration:	200 µM
Incubation Time:	1, 2, 4 h
Result:	Induced apoptosis with the increased the expression of c-PARP.

Molecular Weight

862.67

Formula

C₅₀H₄₃Br₂N₂P

CAS No.

2388983-64-8

SMILES

C1([P+](C2=CC=CC=C2)(C3=CC=CC=C3)CCCC4=[N+](C5=C(N4CC6=CC7=C(C=C6)C=CC=C7)C=CC=C5)CC8=CC=C9C=CC=CC9=C8)=CC=CC=C1.[Br-].[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stromyer ML, et al. Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines. Eur J Med Chem. 2020 Jan 1;185:111832. [Content Brief]