2. PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. PI4K Potassium Channel
  4. Antimalarial agent 41

Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models.

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Antimalarial agent 41 Chemical Structure

Antimalarial agent 41 Chemical Structure

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Antimalarial agent 41 Related Antibodies

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Description

Antimalarial agent 41 (Compound 17) exhibits antimalarial activity, which inhibits Plasmodium falciparum with an IC50 of 40 nM (NF54 strain) and 76 nM (K1 strain). Antimalarial agent 41 is an inhibitor for P. falciparum phosphatidylinositol-4-kinase β (Pf PI4K) and hERG channel, with an IC50 of 53 nM and 3 μM. Antimalarial agent 41 exhibits cytotoxicity to CHO cells with an IC50 of 34 μM. Antimalarial agent 41 ameliorates the malaria infection and exhibits good pharmacokinetic characters in mouse models[1].

IC50 & Target

Pf PI4K

53 nM (IC50)

Molecular Weight

373.37

Formula

C19H18F3N5
SMILES

FC(C1=CC=C(C2=CC=C3N=CC=C(NC4CCNCC4)C3=N2)C=N1)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antimalarial agent 41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antimalarial agent 41Antimalarial agent41Antimalarial agent-41PI4KPotassium ChannelPhosphatidylinositol 4 kinasesPI4 kinasesKcsAPlasmodium falciparumNSG mouseantimalarialInhibitorinhibitorinhibit

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