Antimalarial agent 44 

Antimalarial agent 44 (Compound 3) is an antimalarial agent against parasite. Antimalarial agent 44 has a good permeability across MDCK-MDR1 cell monolayers and a high clearance by mouse liver microsomes^[1].

Antimalarial agent 44 inhibits Leishmania infantum, Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense and Trypanosoma cruzi (EC₅₀: 1.8, 3, 15, 9.1, 20 μM, respectively) ^[1].
Antimalarial agent 44 (pH 7.4) has a good cell permeability across MDCK-MDR1 cell monolayers, with P_app AB of 3.5 μcm/s^[1].
Antimalarial agent 44 (pH 7.4) was efficiently cleared in mouse liver microsomes, with CL_int of >580 μL/min/mg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

663.72

C₃₇H₃₇N₅O₇

O=C(C1=CC(NC(C2=NC=CC=C2)=O)=C(C=C1)OC3=CC=C(C[C@@H]4NC(OC(C)(C)C)=O)C=C3)CNC([C@H](CC5=CC=CC=C5)NC4=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Riu, et al. Discovery of a Series of Macrocycles as Potent Inhibitors of Leishmania Infantum. Journal of medicinal chemistry, 2024, 67(20):18170-18193.  [Content Brief]