Antiproliferative agent-12 

Antiproliferative agent-10 (compound 1) is an anti-tumour ruthenium(II)-tris-pyrazolylmethane complex that inhibits the growth of cancer cells by inhibiting mitochondrial calcium uptake^[1].

Antiproliferative agent-10 (compound 1) (1.5-5.8 μM, 72 h) has significantly anti-cancer cell proliferative activity and effectively induces apoptosis in HCT116 cells^[1].
Antiproliferative agent-10 (15 μM, 24 h) shows HCT116 cell survival rates of 93% to 97% and ruthenium content of cell was 145.1 ng/10⁶ cells, so that it can accumulate efficiently in the cells and promote their biological activity^[1].
Antiproliferative agent-10 (3-10 μM, 5 h) can cause mitochondrial depolarization in a concentration-dependent manner and inhibit mitochondrial calcium uptake^[1].
Antiproliferative agent-10 can inhibit the formation and growth of spheroids of HCT116 cells with an IC₅₀ value of 2.5 μM, approximately 18-fold more effective than cisplatin and almost completely disintegrate of the spheroids^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

910.79

C₄₆H₄₀Cl₂N₆P₂Ru

[H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](C8=CC=CC=C8)(C9=CC=CC=C9)C%10=CC=CC=C%10)n%11n1ccc%11.[Cl-]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jakub Cervinka, et al. Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis. J Med Chem. 2022 Aug 1.  [Content Brief]