2. Apoptosis
  3. Apoptosis
  4. Antiproliferative agent-19

Antiproliferative agent-19 (compound 4a) is an anti-cancer agent that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase.

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Antiproliferative agent-19 Chemical Structure

Antiproliferative agent-19 Chemical Structure

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Antiproliferative agent-19 Related Antibodies

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Description

Antiproliferative agent-19 (compound 4a) is an anti-cancer agent that exerts anti-proliferative effects on lung cancer cells by inducing apoptosis. antiproliferative agent-19 also induces cell cycle arrest in the G2/M phase[1].

In Vitro

Antiproliferative agent-19 (0-50 µM; 72 h) significantly inhibits the viability of human nonsmall cell lung cancer and colon cancer cells[1].
Antiproliferative agent-19 (11.33 µM; 24, 48, and 72 h) induces sub‑G1‑phase cell cycle arrest in A549 cells[1].
Antiproliferative agent-19 (11.33 µM; 6, 24 and 48 h) induces apoptosis via intrinsic and extrinsic pathways in A549 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-19 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HCT-116 and A549 cells
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Inhibited the growth of HCT-116 and A549 cells with IC50 values of 12.18 and 11.33 µM, respectively.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 11.33 µM
Incubation Time: 24, 48, and 72 h
Result: Increased cells of G2 phase significantly from 3.2% (DMSO-treated cells) to 15.5% and 33.8% (cells treated with the compound for 24 and 48 h, respectively).

Apoptosis Analysis[1]

Cell Line: A549 cells
Concentration: 11.33 µM
Incubation Time: 6, 24 and 48 h
Result: Induced caspase-dependent cell death.
Molecular Weight

365.47

Formula

C26H23NO
SMILES

O=C1NC2=C(CCCC2)C(C3=CC=CC=C3)=C1CC4=C5C=CC=CC5=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-19 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-19Antiproliferative agent19Antiproliferative agent 19Apoptosisanti-proliferationapoptosiscell cycle arrestcancerG2/MHCT-116 cellA549 cellInhibitorinhibitorinhibit

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