Antiproliferative agent-4 

Antiproliferative agent-4 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative agent-4 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative agent-4 inhibits tumour growth in nude mice, with low toxicity^[1].

IC₅₀: 0.13 ± 0.01 μM in EC109, 0.27 ± 0.02 μM in TE-1, 0.20 ± 0.01 μM in MGC-803, 0.35 ± 0.03 μM in MCF-7^[1]

Antiproliferative agent-4 has inhibitory activity against cancer cell lines EC109, TE-1, MGC-803 and MCF-7 with IC₅₀s of 0.13 ± 0.01 μM, 0.27 ± 0.02 μM, 0.20 ± 0.01 μM and 0.35 ± 0.03 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

547.04

C₂₉H₃₅ClO₈

CC1(C)CCC[C@]2(COC(O)=O)C1C[C@@H](O)[C@]3(C4=O)C2[C@@H](O)C[C@@H](C4=C)[C@H]3OC(C5=CC=C(CCl)C=C5)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huo JF, et al. Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents. Eur J Med Chem. 2020;208:112789.  [Content Brief]