2. Apoptosis
  3. Apoptosis
  4. Antiproliferative agent-43

Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase.

For research use only. We do not sell to patients.

Antiproliferative agent-43 Chemical Structure

Antiproliferative agent-43 Chemical Structure

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Antiproliferative agent-43 Related Antibodies

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Description

Antiproliferative agent-43 (Compound e4 ) has notable cytotoxic effects against cancer cell lines and causes apoptosis by stopping the cell cycle at G1 phase[1].

In Vitro

Antiproliferative agent-43 (0, 1.23, 2.45, 2.90 μM, 48 h) induces G1 phase cell cycle arrest in K562 cells, accompanied by abnormal nuclear morphology [1].
Antiproliferative agent-43 (0, 1.23, 2.45 , 2.90 μM, 48 h) apoptosis induces by mitochondrial pathway in K562 cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-43 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: K562
Concentration: 0, 1.23, 2.45 , 2.90 μM
Incubation Time: 48h
Result: Induced G1 phase cell cycle arrest in the K562 cell line.

Apoptosis Analysis[1]

Cell Line: K562
Concentration: 0, 1.23, 2.45 , 2.90 μM
Incubation Time: 48h
Result: The apoptotic cells induced by antiproliferative agent-43 increased from 6.35% in the negative control to 13.36, 37.99, and 64.94%, with a concentration-dependent manner.
Molecular Weight

772.07

Formula

C45H57NO6S2
SMILES

COC1=CC=C(C[C@H](N(CC2)C)[C@](C=C3OC)([H])[C@@]42CC3=O)C4=C1OCCCCOC(CCCCC(SCC5=CC=CC=C5)CCSCC6=CC=CC=C6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antiproliferative agent-43 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-43Antiproliferative agent43Antiproliferative agent 43ApoptosisAntiproliferativeLeukemiaK562 cellsInhibitorinhibitorinhibit

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