Antitubercular agent-27 

Antitubercular agent-27 (compound 1) is a potent antitubercular agent with an IC₅₀ value of 3.2 µM, an MIC value of 7.8 µM, an IC₉₀ value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity^[1].

Antitubercular agent-27 (compound 1) shows antimycobacterial activity for resistant isolates of M. tuberculosis H37Rv with IC₅₀s of 2.4, 100, 120, 1.3, 3.1 µM, MICs of 3.2, 140, 160, 2.4, 4.2 µM, IC₉₀s of 3.0, 120, 142, 2.2, 3.5 µM for FQ-R1, INH-R1, INH-R2, RIF-R1, RIF-R2, respectively^[1].
Antitubercular agent-27 (0-200 µM) shows antibacterial activity with an MIC value of 0.80 µM, IC₅₀ value of 0.23 µM, and IC₉₀ value of 0.43 µM in low oxygen condition, and an MIC value of 0.45 µM, IC₅₀ value of 0.27 µM, and IC₉₀ value of 0.35 µM in normal oxygen condition^[1].
Antitubercular agent-27 (0-200 µM) shows intracellular activity with an IC₅₀ value of 1.45 µM, and IC₉₀ value of 1.61 µM, and low cytotoxicity with an IC₅₀ value of >100 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

346.14

C₁₄H₈BrN₃O₃

2460651-09-4

O=C(NN(C(C1=C2C=CC=C1Br)=O)C2=O)C3=CC=NC=C3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Patel H, et al. Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis. Bioorg Chem. 2020 Sep;102:104099.  [Content Brief]