2. Immunology/Inflammation
  3. STING
  4. Antitumor agent-114

Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research.

For research use only. We do not sell to patients.

Antitumor agent-114 Chemical Structure

Antitumor agent-114 Chemical Structure

CAS No. : 2757762-91-5

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Antitumor agent-114 Related Antibodies

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Description

Antitumor agent-114 is a potent stimulator of interferon genes (STING) agonist. Antitumor agent-114 activates immunity and reduces tumor volume in a mouse model of breast cancer. Antitumor agent-114 can be used for immunity and cancer diseases research[1].

In Vivo

Antitumor agent-114 (compound 14c) (2, 0.67, 0.22 mg/kg for intratumoral on day 1, 4, and 7) modulates tumor eradication by systemic immune activation in 4T1 tumor-bearing mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T1 tumor-bearing mice model[1]
Dosage: 2, 0.67, 0.22 mg/kg
Administration: Intratumoral (i.t.)
Result: Reached 80 and 70% tumor growth inhibition (TGI) in the groups treated with 2 and 0.67 mg/kg.
Induced tumor regression in 7 of 8 mice at a dose of 2 mg/kg.
Molecular Weight

966.82

Formula

C39H50F2N10O13P2
CAS No.
SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP4(OCOC(C5(C)CCCCC5)=O)=O)[C@@H](OP(OCOC(C6(C)CCCCC6)=O)(C=C[C@@H]7[C@@H](O4)[C@@H](F)[C@H](N8C(N=CN=C9N)=C9N=C8)O7)=O)[C@H]3F
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Antitumor agent-114 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-1142757762-91-5Antitumor agent114Antitumor agent 114STINGStimulator of Interferon GenesTMEM173MITAERISMPYScancerintratumoral administrationimmunotherapyInhibitorinhibitorinhibit

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