2. Metabolic Enzyme/Protease Cytoskeleton Cell Cycle/DNA Damage Immunology/Inflammation NF-κB
  3. Hexokinase Microtubule/Tubulin Reactive Oxygen Species
  4. Antitumor agent-190

Antitumor agent-190 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. Antitumor agent-190 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle.

For research use only. We do not sell to patients.

Antitumor agent-190 Chemical Structure

Antitumor agent-190 Chemical Structure

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Antitumor agent-190 Related Antibodies

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Description

Antitumor agent-190 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. Antitumor agent-190 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle[1].

IC50 & Target

Hexokinase 2

 

Molecular Weight

518.54

Formula

C26H22N4O6S
SMILES

O=C(C1=CN=CC=C1)/C=C/C2=CN(S(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O)C(C2=C4)=CC=C4N5CCOCC5
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Purity & Documentation
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Antitumor agent-190 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-190Antitumor agent190Antitumor agent 190HexokinaseMicrotubule/TubulinReactive Oxygen SpeciesMD-MBA-231ROSapoptosiscell cycleMMPInhibitorinhibitorinhibit

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