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  4. Antitumor agent-38

Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

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Antitumor agent-38 Chemical Structure

Antitumor agent-38 Chemical Structure

CAS No. : 2744193-34-6

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Antitumor agent-38 Related Antibodies

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Description

Antitumor agent-38 is a potent antitumor agents. Antitumor agent-38 shows antiproliferative activity for cancer cells. Antitumor agent-38 induces cell cycle arrest at the late S and G2/M phase without interfering with microtubule formation or cell morphology[1].

Cellular Effect
Cell Line Type Value Description References
A549 GI50
0.66 μM
Compound: 9h
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
KB GI50
0.76 μM
Compound: 9h
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human KB cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
MCF7 GI50
3.67 μM
Compound: 9h
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
MDA-MB-231 GI50
0.85 μM
Compound: 9h
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
[PMID: 34917259]
In Vitro

Antitumor agent-38 (compound 9h) shows antiproliferative activity with GI50s of 0.66, 0.85, 0.76, 4.12, 3.67 µM for A549, MDA-MB-231, KB, KB-VIN, MCF-7 cells, respectively[1].
Antitumor agent-38 (0.58, 1.74 µM; 24 h) induces cell cycle arrest at the late S and G2/M phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-38 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.85, 1.74 µM
Incubation Time: 24 h
Result: Cells were arrested at the late S and G2/M phase.
Molecular Weight

380.44

Formula

C22H24N2O4
CAS No.
SMILES

OC1=CC2=C(CN3CCC(N)CC3)C=C4C=C(OCO5)C5=CC4=C2C=C1OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antitumor agent-38 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-382744193-34-6Antitumor agent38Antitumor agent 38OthersMDA-MB-231 cellsantitumorS and G2/M phasemicrotubule formationncell morphologyPhenanthrene-based tylophorine-1 (PBT-1)Inhibitorinhibitorinhibit

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