1. Membrane Transporter/Ion Channel Apoptosis
  2. Apoptosis BCRP
  3. Antitumor photosensitizer-4

Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells.

For research use only. We do not sell to patients.

Antitumor photosensitizer-4 Chemical Structure

Antitumor photosensitizer-4 Chemical Structure

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Description

Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells[1].

In Vitro

Antitumor photosensitizer-4 arrests cell cycle at S phase,

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor photosensitizer-4 () inhibits tumor growth and prolong survival time on BALB/c nude mice bearing HepG2 xenograft tumor.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1269.90

Formula

C65H77ClN12O11S

SMILES

CC1=C(/C=C2[C@@H](C)[C@H](CCC(O)=O)C3=N/2)NC(/C=C4C(C)=C(CC)C(/C=C(N/5)/C(C)=C(C(O)=O)C5=C3/CC(NCCOCCOCCOCCC(OCCN6CCN(C7=CC(NC8=NC=C(C(NC9=C(C)C=CC=C9Cl)=O)S8)=NC(C)=N7)CC6)=O)=O)=N/4)=C1C=C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Antitumor photosensitizer-4
Cat. No.:
HY-156092
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