APHA Compound 8

Cat. No.: HY-124022: FAQs
Data Sheet Handling Instructions

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APHA Compound 8 (Compound 4) is a histone deacetylase (HDAC) inhibitor. APHA Compound 8 has antimouse HDAC1 activity with an IC₅₀ value of 0.78 μM. APHA Compound 8, as antiproliferative and cytodifferentiating agent on MEL cells, shows dose-dependent growth inhibition and hemoglobin accumulation effects.

For research use only. We do not sell to patients.

APHA Compound 8 Chemical Structure

CAS No. : 676599-90-9

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•Related Small Molecules:

•Related Proteins:

View All HDAC Isoform Specific Products:

View All Isoforms

HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

IC50: 0.78 μM (HDAC1)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Vero	IC₅₀	> 20 μM Compound: 15; APHA-7	Cytotoxicity against African green monkey Vero cells by neutral red assay Cytotoxicity against African green monkey Vero cells by neutral red assay	[PMID: 28241112]

Molecular Weight

284.31

Formula

C₁₆H₁₆N₂O₃

CAS No.

676599-90-9

SMILES

CN1C=C(C=C1/C=C/C(NO)=O)C(CC2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ragno R, et al. 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. J Med Chem. 2004 Mar 11;47(6):1351-9. [Content Brief]

APHA Compound 8 Related Classifications

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Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APHA Compound 8676599-90-9APHA Compound8APHA Compound-8HDACHistone deacetylaseshistone deacetylase (HDAC)antiproliferativecytodifferentiatinghemoglobin accumulationtumorInhibitorinhibitorinhibit

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