Apilimod hydrochloride (Synonyms: STA 5326 hydrochloride; LAM-002A (free base) hydrochloride; AIT-101 hydrochloride)

Cat. No.: HY-14644B: FAQs
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Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.

For research use only. We do not sell to patients.

Apilimod hydrochloride Chemical Structure

CAS No. : 870087-37-9

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NLRP3 NLRP1 NOD1 NOD2

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Description	Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.
Molecular Weight	491.41
Formula	C₂₃H₂₈Cl₂N₆O₂
CAS No.	870087-37-9
SMILES	CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.Cl.Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19 [Content Brief]

Apilimod hydrochloride Related Classifications

Inflammation/Immunology Infection

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apilimod870087-37-9STA 5326LAM-002A free baseAIT-101STA5326STA-5326AIT101AIT 101NOD-like Receptor (NLR)Inhibitorinhibitorinhibit

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Apilimod hydrochloride (Synonyms: STA 5326 hydrochloride; LAM-002A (free base) hydrochloride; AIT-101 hydrochloride)

Apilimod hydrochloride Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All NOD-like Receptor (NLR) Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review