Apoptosis inducer 17

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Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells.

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Apoptosis inducer 17 Chemical Structure

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Description

Apoptosis inducer 17 is a Curcumin-Piperlongumine hybrid molecule that increases cell cycle arrest and apoptosis through activating JNK signaling pathway in lung cancer cells^[1].

In Vitro

Apoptosis inducer 17 (compound CP; 0.027-60 μM; 72 h) inhibits cell proliferation, with IC₅₀ values of 0.021 μM, 0.027 μM, and 0.73 μM for H446, H1299, and SBC-2 cells, respectively^[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) displays superior inhibition of colony formation. Apoptosis inducer 17 induces dose-dependent G2/M arrest in H446 and H1299 cells^[1].
Apoptosis inducer 17 (compound CP; 0.03-0.3 μM; 24 h) induces apoptosis of H446 and H1299 cells is mediated by caspase activity. And also activates JNK signaling cascade^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	H446, H1299, and SBC-2 cells
Concentration:	60 μM, 20 μM, 6.67 μM, 2.22 μM, 0.74 μM, 0.25 μM, 0.082 μM, and 0.027 μM
Incubation Time:	72 h
Result:	Effectively inhibited cell proliferation.

Cell Cycle Analysis^[1]

Cell Line:	H446, H1299 cells
Concentration:	0.03 μM, 0.1 μM, 0.3 μM
Incubation Time:	24 h
Result:	Induced dose-dependent G2/M arrest.

Apoptosis Analysis^[1]

Cell Line:	H446, H1299 cells
Concentration:	0.03 μM, 0.1 μM, 0.3 μM
Incubation Time:	24 h
Result:	Induced apoptosis of H446 and H1299 cells.

Western Blot Analysis^[1]

Cell Line:	H446, H1299 cells
Concentration:	0.03 μM, 0.1 μM, 0.3 μM
Incubation Time:	24 h
Result:	Led to a dose-dependent increase in the phosphorylation of JNK, c-Jun and activating transcription factor-2 (ATF-2) in both H446 and H1299 cells.

In Vivo

Apoptosis inducer 17 (compound CP; 10 mg/kg; ip; twice a day; for 15 days) shows a significant reduction in H446 cell growth, without any significant changes in body weight^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c nude mice (4-6 weeks old) injected with H446 cells^[1]
Dosage:	10 mg/kg
Administration:	ip; twice a day; for 15 days
Result:	Prevented growth of lung cancer in xenograft tumors.

Molecular Weight

453.48

Formula

C₂₅H₂₇NO₇

SMILES

O=C1N(C(/C=C/C2=CC(OC)=C(OC)C(OC)=C2)=O)CCC/C1=C\C3=CC=C(O)C(OC)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Curcumin-Piperlongumine Hybrid Molecule Increases Cell Cycle Arrest and Apoptosis in Lung Cancer through JNK/c-Jun Signaling Pathway [Content Brief]